Running code on startup
Factor handbook ยป The implementation

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Factor looks for three optional files in the user's home directory.
Bootstrap initialization file
Startup initialization file
Additional vocabulary roots file

The -no-user-init command line switch will inhibit loading running of these files.

Here is an example .factor-boot-rc which sets up your developer name:
USING: tools.scaffold namespaces ; "Sheeple Sheepleton" developer-name set-global