The bootstrap initialization file is named .factor-boot-rc. This file can contain require calls for vocabularies you use frequently, and other such long-running tasks that you do not want to perform every time Factor starts.

A word to run this file from an existing Factor session:

run-bootstrap-init ( -- )

For example, if you changed .factor-boot-rc and do not want to bootstrap again, you can just invoke run-bootstrap-init in the listener.